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Energetics and Location of Phosphoinositide Binding in Human Kir2.1 Channels
Kir2.1 channels are uniquely activated by phosphoinositide 4,5-bisphosphate (PI(4,5)P(2)) and can be inhibited by other phosphoinositides (PIPs). Using biochemical and computational approaches, we assess PIP-channel interactions and distinguish residues that are energetically critical for binding fr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675606/ https://ncbi.nlm.nih.gov/pubmed/23564459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.452540 |
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