Identification of a Cholesterol-Binding Pocket in Inward Rectifier K(+) (Kir) Channels

Cholesterol is the major sterol component of all mammalian plasma membranes. Recent studies have shown that cholesterol inhibits both bacterial (KirBac1.1 and KirBac3.1) and eukaryotic (Kir2.1) inward rectifier K(+) (Kir) channels. Lipid-sterol interactions are not enantioselective, and the enantiom...

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Udgivet i:Biophys J
Main Authors: Fürst, Oliver, Nichols, Colin G., Lamoureux, Guillaume, D’Avanzo, Nazzareno
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2014
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269788/
https://ncbi.nlm.nih.gov/pubmed/25517146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.066
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