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Direct and Specific Activation of Human Inward Rectifier K(+) Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

Many ion channels are modulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)), but studies examining the PIP(2) dependence of channel activity have been limited to cell expression systems, which present difficulties for controlling membrane composition. We have characterized the PIP(2) dependenc...

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Main Authors: D'Avanzo, Nazzareno, Cheng, Wayland W. L., Doyle, Declan A., Nichols, Colin G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988318/
https://ncbi.nlm.nih.gov/pubmed/20921230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.186692
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