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The Role of the Cytoplasmic Pore in Inward Rectification of Kir2.1 Channels
Steeply voltage-dependent block by intracellular polyamines underlies the strong inward rectification properties of Kir2.1 and other Kir channels. Mutagenesis studies have identified several negatively charged pore-lining residues (D172, E224, and E299, in Kir2.1) in the inner cavity and cytoplasmic...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151631/ https://ncbi.nlm.nih.gov/pubmed/17635958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709742 |
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