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Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells

Double-strand break (DSB) repair pathways are critical for the maintenance of genomic integrity and the prevention of tumorigenesis in mammalian cells. Here, we present the development and validation of a novel assay to measure mutagenic non-homologous end-joining (NHEJ) repair in living cells, whic...

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Detalles Bibliográficos
Main Authors: Bindra, Ranjit S., Goglia, Alexander G., Jasin, Maria, Powell, Simon N.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675474/
https://ncbi.nlm.nih.gov/pubmed/23585275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt255
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