Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis

There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT. The development of oral medications is a key objective of the Consor...

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Bibliografiske detaljer
Main Authors: Thuita, John K., Wolf, Kristina K., Murilla, Grace A., Liu, Qiang, Mutuku, James N., Chen, Yao, Bridges, Arlene S., Mdachi, Raymond E., Ismail, Mohamed A., Ching, Shelley, Boykin, David W., Hall, James Edwin, Tidwell, Richard R., Paine, Mary F., Brun, Reto, Wang, Michael Zhuo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674995/
https://ncbi.nlm.nih.gov/pubmed/23755309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002230
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