Phase I Pharmacokinetic and Pharmacodynamic Study of Cetuximab, Irinotecan and Sorafenib in Advanced Colorectal Cancer

BACKGROUND: This phase Ib study was designed to determine the maximum tolerated doses (MTD) and dose limiting toxicities (DLTs) of irinotecan and cetuximab with sorafenib. Secondary objectives included characterizing the pharmacokinetics and pharmacodynamics and evaluating preliminary antitumor acti...

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Main Authors: Azad, Nilofer, Dasari, Arvind, Arcaroli, John, Taylor, Gretchen E., Laheru, Daniel A., Carducci, Michael A., McManus, Martine, Quackenbush, Kevin, Wright, John J., Hidalgo, Manuel, Diaz, Luis A., Donehower, Ross C., Zhao, Ming, Rudek, Michelle A., Messersmith, Wells A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674958/
https://ncbi.nlm.nih.gov/pubmed/22615057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9820-z
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