A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias

We report the results of a Phase I dose escalation trial of the multikinase inhibitor sorafenib in relapsed/refractory acute leukemias using an intermittent dosing regimen. Fifteen patients with advanced leukemia (Acute myeloid leukemia(AML), 2=Acute lymphoblastic leukemia(ALL), 1 Biphenotypic) and...

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Detalhes bibliográficos
Main Authors: Pratz, Keith W., Cho, Eunpi, Levis, Mark J., Karp, Judith E., Gore, Steven D., McDevitt, Michael, Stine, Adam, Zhao, Ming, Baker, Sharyn D., Carducci, Michael A., Wright, John J., Rudek, Michelle A., Smith, B. Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921005/
https://ncbi.nlm.nih.gov/pubmed/20535150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.132
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