Phase 1 Dose- Escalation Trial of Clofarabine Followed by Escalating Dose of Fractionated Cyclophosphamide in Adults with Relapsed or Refractory Acute Leukaemias

The prognosis of patients with relapsed and refractory acute leukaemia (RRAL) is very poor. Forty patients with RRAL were enrolled (28 acute myeloid leukaemia [AML], 12 acute lymphoblastic leukaemia [ALL]) in this Phase 1 dose-escalation trial of daily-infused clofarabine (CLO) followed by cyclophos...

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Main Authors: Zeidan, Amer M, Ricklis, Rebecca M, Carraway, Hetty E, Yun, Hyun D, Greer, Jacqueline M, Smith, B Douglas, Levis, Mark J, McDevitt, Michael A, Pratz, Keith W, Showel, Margaret M, Gladstone, Douglas E, Gore, Steven D, Karp, Judith E
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389586/
https://ncbi.nlm.nih.gov/pubmed/22594769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2012.09142.x
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