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INHIBITORS OF HYDROPEROXIDE METABOLISM ENHANCE ASCORBATE-INDUCED CYTOTOXICITY

Pharmacological ascorbate, via its oxidation, has been proposed as a pro-drug for the delivery of H(2)O(2) to tumors. Pharmacological ascorbate decreases clonogenic survival of pancreatic cancer cells, which can be reversed by treatment with scavengers of H(2)O(2). The goal of this study was to dete...

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Autors principals: Olney, Kristen E., Du, Juan, van 't Erve, Thomas J., Witmer, Jordan R., Sibenaller, Zita A., Wagner, Brett A., Buettner, Garry R., Cullen, Joseph J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674878/
https://ncbi.nlm.nih.gov/pubmed/23205739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2012.755263
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