A Co-Receptor Independent Transgenic Human TCR Mediates Anti-Tumor and Anti-Self Immunity in Mice

Recent advancements in T cell immunotherapy suggest that T cells engineered with high affinity T cell receptors (TCR) can offer better tumor regression. However, whether a high affinity TCR alone is sufficient to control tumor growth, or the T cell subset bearing the TCR is also important remains un...

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Detalhes bibliográficos
Main Authors: Mehrotra, Shikhar, Al-Khami, Amir A., Klarquist, Jared, Husain, Shahid, Naga, Osama, Eby, Jonathan M., Murali, Anuradha K., Lyons, Gretchen E., Li, Mingli, Spivey, Natali D., Norell, Håkan, Martins da Palma, Telma, Onicescu, Georgiana, Diaz-Montero, C. Marcela, Garrett-Mayer, Elizabeth, Cole, David J., Le Poole, I. Caroline, Nishimura, Michael I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674773/
https://ncbi.nlm.nih.gov/pubmed/22798675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103271
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