CD47 fusion protein targets CD172a(+) cells in Crohn’s disease and dampens the production of IL-1β and TNF

In mice, the transfer of CD172a(+) (SIRP-α) dendritic cells (DCs) elicits T cell–driven colitis, whereas treatment with CD47-Fc protein, a CD172a-binding agent, confers protection. The aim of this study was to elucidate the nature and functional properties of human CD172a(+) DCs in chronic intestina...

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Main Authors: Baba, Nobuyasu, Van, Vu Quang, Wakahara, Keiko, Rubio, Manuel, Fortin, Geneviève, Panzini, Benoît, Soucy, Geneviève, Wassef, Ramses, Richard, Carole, Tamaz, Raja, Lahaie, Raymond, Bernard, Edmond-Jean, Caussignac, Yves, Leduc, Raymond, Lougnarath, Rasmy, Bergeron, Carole, Racicot, Marc-André, Bergeron, Fanny, Panzini, Marie-Andrée, Demetter, Pieter, Franchimont, Denis, Schäkel, Knut, Weckbecker, Gisbert, Kolbinger, Frank, Heusser, Christoph, Huber, Thomas, Welzenbach, Karl, Sarfati, Marika
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674701/
https://ncbi.nlm.nih.gov/pubmed/23669395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122037
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