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LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity
Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are indispensable for NK-cell cytotoxicity because their release results in the induction of target-cell apoptosis. Lysosome-associated membrane protein (LAMP) 1/CD107a is used as a marker for NK-cell degranulation,...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674668/ https://ncbi.nlm.nih.gov/pubmed/23632890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-453738 |
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