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LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are indispensable for NK-cell cytotoxicity because their release results in the induction of target-cell apoptosis. Lysosome-associated membrane protein (LAMP) 1/CD107a is used as a marker for NK-cell degranulation,...

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Bibliografske podrobnosti
Main Authors: Krzewski, Konrad, Gil-Krzewska, Aleksandra, Nguyen, Victoria, Peruzzi, Giovanna, Coligan, John E.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674668/
https://ncbi.nlm.nih.gov/pubmed/23632890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-453738
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