Chediak-Higashi syndrome: LYST domains regulate exocytosis of lytic granules, but not cytokine secretion by NK cells

BACKGROUND: Mutations in LYST cause Chediak-Higashi syndrome (CHS), a rare immunodeficiency with impaired cytotoxic lymphocyte function, mainly that of natural killer (NK) cells. Our understanding of NK cell function deficiency in CHS, and how LYST regulates lytic granule exocytosis is very limited....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Gil-Krzewska, Aleksandra, Wood, Stephanie M., Murakami, Yousuke, Nguyen, Victoria, Chiang, Samuel Cern Cher, Cullinane, Andrew R., Giovanna, Peruzzi, Gahl, William A., Coligan, John E., Introne, Wendy J., Bryceson, Yenan T., Krzewski, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826811/
https://ncbi.nlm.nih.gov/pubmed/26478006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.08.039
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados