Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners

Polyglutamine (polyQ) diseases are genetically inherited neurodegenerative disorders. They are caused by mutations that result in polyQ expansions of particular proteins. Mutant proteins form intranuclear aggregates, induce cytotoxicity and cause neuronal cell death. Protein interaction data suggest...

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Hlavní autoři: Petrakis, Spyros, Schaefer, Martin H, Wanker, Erich E, Andrade-Navarro, Miguel A
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Insights & Perspectives
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674527/
https://ncbi.nlm.nih.gov/pubmed/23483542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201300001
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