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Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans
MicroRNAs (miRNAs) post-transcriptionally repress gene expression via the miRNA-induced silencing complex (miRISC), which includes miRNA, Argonaute and a GW182 family member. Here we show that in Caenorhabditis elegans, miRNA-mediated gene silencing is modulated by macroautophagy, a lysosome-mediate...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
European Molecular Biology Organization
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674441/ https://ncbi.nlm.nih.gov/pubmed/23619095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.53 |
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