Systematic identification of miRISC proteins, miRNAs, and their mRNA targets in C. elegans by their interactions with GW182 family proteins AIN-1 and AIN-2

MicroRNAs (miRNAs) regulate gene expression for diverse functions, but only a limited number of mRNA targets have been experimentally identified. We show that GW182 family proteins AIN-1 and AIN-2 act redundantly to regulate the expression of miRNA targets, but not miRNA biogenesis. Immunoprecipitat...

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Detalhes bibliográficos
Main Authors: Zhang, Liang, Ding, Lei, Cheung, Tom H., Dong, Meng-Qiu, Chen, Jun, Sewell, Aileen K., Liu, Xuedong, Yates, John R., Han, Min
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186060/
https://ncbi.nlm.nih.gov/pubmed/18042455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.09.014
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