HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3′-untranslated regions (3′-UTR) can be relieved of miRNA repression under cellular stress in a process involving the embryonic leth...

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Hlavní autoři: Kundu, Pradipta, Fabian, Marc R., Sonenberg, Nahum, Bhattacharyya, Suvendra N., Filipowicz, Witold
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367187/
https://ncbi.nlm.nih.gov/pubmed/22362743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks148
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