Clonal Expansion of Mitochondrial DNA Deletions in Multiple Sclerosis

OBJECTIVE: Mitochondrial DNA deletions (Δ-mtDNA) are implicated in the pathogenesis of multiple sclerosis (MS), Parkinson’s disease (PD), Alzheimer’s disease (AD) and ageing. Given the diffuse nature of inflammation in MS, aim of this study was to determine whether Δ-mtDNA caused respiratory deficie...

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Hauptverfasser: Campbell, Graham R, Kraytsberg, Yevgenya, Krishnan, Kim J, Ohno, Nobuhiko, Ziabreva, Iryna, Reeve, Amy, Newcombe, Jia, Reynolds, Richard, Lassmann, Hans, Khrapko, Konstantin, Turnbull, Doug M, Mahad, Don J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674417/
https://ncbi.nlm.nih.gov/pubmed/22688405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-1001-9
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