Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

Cancer cells may survive under oxygen and nutrient deprivation by metabolic reprogramming for high levels of anaerobic glycolysis, which contributes to tumor growth and drug resistance. Abnormally expressed glucose transporters (GLUTs) are colocalized with hypoxia (Hx) inducible factor (HIF)1α in pe...

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Bibliographic Details
Main Authors: Huang, C-Y, Kuo, W-T, Huang, Y-C, Lee, T-C, Yu, L C H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674358/
https://ncbi.nlm.nih.gov/pubmed/23640464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.149
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