Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

Cancer cells may survive under oxygen and nutrient deprivation by metabolic reprogramming for high levels of anaerobic glycolysis, which contributes to tumor growth and drug resistance. Abnormally expressed glucose transporters (GLUTs) are colocalized with hypoxia (Hx) inducible factor (HIF)1α in pe...

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Detalhes bibliográficos
Main Authors: Huang, C-Y, Kuo, W-T, Huang, Y-C, Lee, T-C, Yu, L C H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674358/
https://ncbi.nlm.nih.gov/pubmed/23640464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.149
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