A caspase-3 ‘death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers

Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor biopsies is a significant challenge and minim...

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Detalhes bibliográficos
Main Authors: Simpson, K L, Cawthorne, C, Zhou, C, Hodgkinson, C L, Walker, M J, Trapani, F, Kadirvel, M, Brown, G, Dawson, M J, MacFarlane, M, Williams, K J, Whetton, A D, Dive, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674346/
https://ncbi.nlm.nih.gov/pubmed/23640455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.137
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