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Synthetic activation of caspases: Artificial death switches

The development of safe vectors for gene therapy requires fail-safe mechanisms to terminate therapy or remove genetically altered cells. The ideal “suicide switch” would be nonimmunogenic and nontoxic when uninduced and able to trigger cell death independent of tissue type or cell cycle stage. By us...

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Detalles Bibliográficos
Main Authors: MacCorkle, Rebecca A., Freeman, Kevin W., Spencer, David M.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC19891/
https://ncbi.nlm.nih.gov/pubmed/9520421
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