Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin–p...

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Détails bibliographiques
Auteurs principaux: Lignitto, Luca, Arcella, Antonietta, Sepe, Maria, Rinaldi, Laura, Delle Donne, Rossella, Gallo, Adriana, Stefan, Eduard, Bachmann, Verena A., Oliva, Maria A., Tiziana Storlazzi, Clelia, L'Abbate, Alberto, Brunetti, Arturo, Gargiulo, Sara, Gramanzini, Matteo, Insabato, Luigi, Garbi, Corrado, Gottesman, Max E., Feliciello, Antonio
Format: Artigo
Langue:Inglês
Publié: Nature Pub. Group 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674242/
https://ncbi.nlm.nih.gov/pubmed/23652010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2791
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