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Mg(2+) binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site
Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e. the DNA base T) and thus is a common target for antibiotic and anticancer drugs. Mg(2+) has been reported to affect TSase activity, but the mechanism of this interaction has not been investigated. Here we...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674108/ https://ncbi.nlm.nih.gov/pubmed/23611499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400761x |
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