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Functional Recurrent Mutations in the Human Mitochondrial Phylogeny: Dual Roles in Evolution and Disease

Mutations frequently reoccur in the human mitochondrial DNA (mtDNA). However, it is unclear whether recurrent mtDNA nodal mutations (RNMs), that is, recurrent mutations in stems of unrelated phylogenetic nodes, are functional and hence selectively constrained. To answer this question, we performed c...

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Detalles Bibliográficos
Autores principales: Levin, Liron, Zhidkov, Ilia, Gurman, Yotam, Hawlena, Hadas, Mishmar, Dan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673625/
https://ncbi.nlm.nih.gov/pubmed/23563965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evt058
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