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Functional Recurrent Mutations in the Human Mitochondrial Phylogeny: Dual Roles in Evolution and Disease

Mutations frequently reoccur in the human mitochondrial DNA (mtDNA). However, it is unclear whether recurrent mtDNA nodal mutations (RNMs), that is, recurrent mutations in stems of unrelated phylogenetic nodes, are functional and hence selectively constrained. To answer this question, we performed c...

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Detalhes bibliográficos
Main Authors: Levin, Liron, Zhidkov, Ilia, Gurman, Yotam, Hawlena, Hadas, Mishmar, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673625/
https://ncbi.nlm.nih.gov/pubmed/23563965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evt058
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