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Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit
Based on modification of separate structural features of the Vibrio cholerae quorum sensing signal, (S)-3-hydroxytridecan-4-one (CAI-1), three focused compound libraries have been synthesized and evaluated for biological activity. Modifications to the acyl tail and α-hydroxy ketone typically provide...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3673537/ https://ncbi.nlm.nih.gov/pubmed/22001326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.021 |
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