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Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit

Based on modification of separate structural features of the Vibrio cholerae quorum sensing signal, (S)-3-hydroxytridecan-4-one (CAI-1), three focused compound libraries have been synthesized and evaluated for biological activity. Modifications to the acyl tail and α-hydroxy ketone typically provide...

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Detalhes bibliográficos
Main Authors: Bolitho, Megan E., Perez, Lark J., Koch, Matthew J., Ng, Wai-Leung, Bassler, Bonnie L, Semmelhack, Martin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673537/
https://ncbi.nlm.nih.gov/pubmed/22001326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.021
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