Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction, but the mechanisms underlying increased mortality are unknown. Mice with streptozotocin-induced diabetes developed profound heart rate slowing and doubled mortality compared with controls after myocardial in...

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Hlavní autoři: Luo, Min, Guan, Xiaoqun, Luczak, Elizabeth D., Lang, Di, Kutschke, William, Gao, Zhan, Yang, Jinying, Glynn, Patric, Sossalla, Samuel, Swaminathan, Paari D., Weiss, Robert M., Yang, Baoli, Rokita, Adam G., Maier, Lars S., Efimov, Igor R., Hund, Thomas J., Anderson, Mark E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673230/
https://ncbi.nlm.nih.gov/pubmed/23426181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65268
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