Oxidized CaMKII causes cardiac sinus node dysfunction in mice

Sinus node dysfunction (SND) is a major public health problem that is associated with sudden cardiac death and requires surgical implantation of artificial pacemakers. However, little is known about the molecular and cellular mechanisms that cause SND. Most SND occurs in the setting of heart failure...

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Autori principali: Swaminathan, Paari Dominic, Purohit, Anil, Soni, Siddarth, Voigt, Niels, Singh, Madhu V., Glukhov, Alexey V., Gao, Zhan, He, B. Julie, Luczak, Elizabeth D., Joiner, Mei-ling A., Kutschke, William, Yang, Jinying, Donahue, J. Kevin, Weiss, Robert M., Grumbach, Isabella M., Ogawa, Masahiro, Chen, Peng-Sheng, Efimov, Igor, Dobrev, Dobromir, Mohler, Peter J., Hund, Thomas J., Anderson, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223923/
https://ncbi.nlm.nih.gov/pubmed/21785215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57833
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