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Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing

OBJECTIVES: One potential concern of once-daily protease inhibitor administration is low trough concentrations and ultimately the ‘forgiveness’ or robustness in comparison with the originally licensed twice-daily dose. To give an estimation of ‘forgiveness’, we determined the length of time plasma d...

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Main Authors: Dickinson, Laura, Boffito, Marta, Khoo, Saye H., Schutz, Malte, Aarons, Leon J., Pozniak, Anton L., Back, David J.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672987/
https://ncbi.nlm.nih.gov/pubmed/18467305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkn187
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