JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

Subclones homozygous for JAK2V617F are more common in polycythemia vera (PV) than essential thrombocythemia (ET), but their prevalence and significance remain unclear. The JAK2 mutation status of 6495 BFU-E, grown in low erythropoietin conditions, was determined in 77 patients with PV or ET. Homozyg...

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Autori principali: Godfrey, Anna L., Chen, Edwin, Pagano, Francesca, Ortmann, Christina A., Silber, Yvonne, Bellosillo, Beatriz, Guglielmelli, Paola, Harrison, Claire N., Reilly, John T., Stegelmann, Frank, Bijou, Fontanet, Lippert, Eric, McMullin, Mary F., Boiron, Jean-Michel, Döhner, Konstanze, Vannucchi, Alessandro M., Besses, Carlos, Campbell, Peter J., Green, Anthony R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672970/
https://ncbi.nlm.nih.gov/pubmed/22898600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-431791
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