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Enantioselective synthesis of (R)-tolterodine using lithiation/borylation–protodeboronation methodology

The synthesis of the pharmaceutical (R)-tolterodine is reported using lithiation/borylation–protodeboronation of a homoallyl carbamate as the key step. This step was tested with two permutations: an electron-neutral aryl Li-carbamate reacting with an electron-rich boronic ester and an electron-rich...

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Hlavní autoři: Roesner, Stefan, Aggarwal, Varinder K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672952/
https://ncbi.nlm.nih.gov/pubmed/23750041
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