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The Mechanism of Na(+)/K(+) Selectivity in Mammalian Voltage-Gated Sodium Channels Based on Molecular Dynamics Simulation
Voltage-gated sodium (Na(v)) channels and their Na(+)/K(+) selectivity are of great importance in the mammalian neuronal signaling. According to mutational analysis, the Na(+)/K(+) selectivity in mammalian Na(v) channels is mainly determined by the Lys and Asp/Glu residues located at the constrictio...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672897/ https://ncbi.nlm.nih.gov/pubmed/23746512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.035 |
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