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The Mechanism of Na(+)/K(+) Selectivity in Mammalian Voltage-Gated Sodium Channels Based on Molecular Dynamics Simulation

Voltage-gated sodium (Na(v)) channels and their Na(+)/K(+) selectivity are of great importance in the mammalian neuronal signaling. According to mutational analysis, the Na(+)/K(+) selectivity in mammalian Na(v) channels is mainly determined by the Lys and Asp/Glu residues located at the constrictio...

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Bibliografiske detaljer
Main Authors: Xia, Mengdie, Liu, Huihui, Li, Yang, Yan, Nieng, Gong, Haipeng
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672897/
https://ncbi.nlm.nih.gov/pubmed/23746512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.035
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