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Multiple Steps to Activate FAK’s Kinase Domain: Adaptation to Confined Environments?

Protein kinases regulate cell signaling by phosphorylating their substrates in response to environment-specific stimuli. Using molecular dynamics, we studied the catalytically active and inactive conformations of the kinase domain of the focal adhesion kinase (FAK), which are distinguished by displa...

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Autors principals: Herzog, Florian A., Vogel, Viola
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672873/
https://ncbi.nlm.nih.gov/pubmed/23746525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.021
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