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Substrate Binding Specifically Modulates Domain Arrangements in Adenylate Kinase

The enzyme adenylate kinase (ADK) features two substrate binding domains that undergo large-scale motions during catalysis. In the apo state, the enzyme preferentially adopts a globally open state with accessible binding sites. Binding of two substrate molecules (AMP + ATP or ADP + ADP) results in a...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Zeller, Fabian, Zacharias, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643206/
https://ncbi.nlm.nih.gov/pubmed/26536274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.08.049
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