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Substrate Binding Specifically Modulates Domain Arrangements in Adenylate Kinase
The enzyme adenylate kinase (ADK) features two substrate binding domains that undergo large-scale motions during catalysis. In the apo state, the enzyme preferentially adopts a globally open state with accessible binding sites. Binding of two substrate molecules (AMP + ATP or ADP + ADP) results in a...
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| Published in: | Biophys J |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643206/ https://ncbi.nlm.nih.gov/pubmed/26536274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.08.049 |
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