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Multiple Steps to Activate FAK’s Kinase Domain: Adaptation to Confined Environments?
Protein kinases regulate cell signaling by phosphorylating their substrates in response to environment-specific stimuli. Using molecular dynamics, we studied the catalytically active and inactive conformations of the kinase domain of the focal adhesion kinase (FAK), which are distinguished by displa...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672873/ https://ncbi.nlm.nih.gov/pubmed/23746525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.021 |
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