ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain

Focal adhesion kinase (FAK) regulates gastrointestinal epithelial restitution and healing. ZINC40099027 (Zn27) activates cellular FAK and promotes intestinal epithelial wound closure in vitro and in mice. However, whether Zn27 activates FAK directly or indirectly remains unknown. We evaluated Zn27 p...

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Bibliografische gegevens
Gepubliceerd in:Pharmacol Res Perspect
Hoofdauteurs: Rashmi, More, Shyam K., Wang, Qinggang, Vomhof‐DeKrey, Emilie E., Porter, James E., Basson, Marc D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955952/
https://ncbi.nlm.nih.gov/pubmed/33715263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.737
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