ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain

Focal adhesion kinase (FAK) regulates gastrointestinal epithelial restitution and healing. ZINC40099027 (Zn27) activates cellular FAK and promotes intestinal epithelial wound closure in vitro and in mice. However, whether Zn27 activates FAK directly or indirectly remains unknown. We evaluated Zn27 p...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Rashmi, More, Shyam K., Wang, Qinggang, Vomhof‐DeKrey, Emilie E., Porter, James E., Basson, Marc D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955952/
https://ncbi.nlm.nih.gov/pubmed/33715263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.737
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