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ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain
Focal adhesion kinase (FAK) regulates gastrointestinal epithelial restitution and healing. ZINC40099027 (Zn27) activates cellular FAK and promotes intestinal epithelial wound closure in vitro and in mice. However, whether Zn27 activates FAK directly or indirectly remains unknown. We evaluated Zn27 p...
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| Publicado no: | Pharmacol Res Perspect |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7955952/ https://ncbi.nlm.nih.gov/pubmed/33715263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.737 |
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