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Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing
GI mucosal healing requires epithelial sheet migration. The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motility. A virtual screen identified the small drug-like FAK mimic ZINC40099027, which activates FAK. We assessed whether ZINC40099027 promotes FAK-Tyr-397 phos...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6789032/ https://ncbi.nlm.nih.gov/pubmed/31604999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51183-z |
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