Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing

GI mucosal healing requires epithelial sheet migration. The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motility. A virtual screen identified the small drug-like FAK mimic ZINC40099027, which activates FAK. We assessed whether ZINC40099027 promotes FAK-Tyr-397 phos...

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Udgivet i:Sci Rep
Main Authors: Wang, Qinggang, More, Shyam K., Vomhof-DeKrey, Emilie E., Golovko, Mikhail Y., Basson, Marc D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789032/
https://ncbi.nlm.nih.gov/pubmed/31604999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51183-z
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