CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease that is involved in the degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regulation in the cartilage of patients with osteoarthritis. Previous studies have...

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Hlavní autoři: Hou, Chun-Han, Tang, Chih-Hsin, Hsu, Chin-Jung, Hou, Sheng-Mon, Liu, Ju-Fang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672729/
https://ncbi.nlm.nih.gov/pubmed/23343403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4151
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