CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease that is involved in the degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regulation in the cartilage of patients with osteoarthritis. Previous studies have...

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Détails bibliographiques
Auteurs principaux: Hou, Chun-Han, Tang, Chih-Hsin, Hsu, Chin-Jung, Hou, Sheng-Mon, Liu, Ju-Fang
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672729/
https://ncbi.nlm.nih.gov/pubmed/23343403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4151
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