Neural Correlates of Rapid Antidepressant Response to Ketamine in Treatment-Resistant Unipolar Depression: A preliminary PET study

BACKGROUND: Multiple lines of evidence support a role for the glutamatergic system in the pathophysiology of major depressive disorder (MDD). Ketamine, an N-methyl-D-aspartate (NMDA) antagonist, rapidly improves depressive symptoms in individuals with treatment-resistant depression. The neural mecha...

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Detalhes bibliográficos
Main Authors: Carlson, Paul J., Diazgranados, Nancy, Nugent, Allison C., Ibrahim, Lobna, Luckenbaugh, David A., Brutsche, Nancy, Herscovitch, Peter, Manji, Husseini K., Zarate, Carlos A., Drevets, Wayne C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672258/
https://ncbi.nlm.nih.gov/pubmed/23540908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.02.008
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