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Tumor immunity times out: TIM-3 and HMGB1
The characteristics of the tumor microenvironment vary widely. New work shows that after tumor-associated expression of the receptor TIM-3 by dendritic cells, TIM-3 inhibits the antitumor efficacy of DNA vaccines and chemotherapy by binding to the damage-associated molecular pattern molecule, HMGB1.
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672065/ https://ncbi.nlm.nih.gov/pubmed/22910384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2396 |
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