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Tumor immunity times out: TIM-3 and HMGB1

The characteristics of the tumor microenvironment vary widely. New work shows that after tumor-associated expression of the receptor TIM-3 by dendritic cells, TIM-3 inhibits the antitumor efficacy of DNA vaccines and chemotherapy by binding to the damage-associated molecular pattern molecule, HMGB1.

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Библиографические подробности
Главные авторы: Tang, Daolin, Lotze, Michael T
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672065/
https://ncbi.nlm.nih.gov/pubmed/22910384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2396
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