Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

The mechanisms by which tumor microenvironments modulate nucleic acid–mediated innate immunity remain unknown. Here we identify the receptor TIM-3 as key in circumventing the stimulatory effects of nucleic acids in tumor immunity. Tumor-associated dendritic cells (DCs) in mouse tumors and patients w...

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Auteurs principaux: Chiba, Shigeki, Baghdadi, Muhammad, Akiba, Hisaya, Yoshiyama, Hironori, Kinoshita, Ichiro, Dosaka-Akita, Hirotoshi, Fujioka, Yoichiro, Ohba, Yusuke, Gorman, Jacob V, Colgan, John D, Hirashima, Mitsuomi, Uede, Toshimitsu, Takaoka, Akinori, Yagita, Hideo, Jinushi, Masahisa
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622453/
https://ncbi.nlm.nih.gov/pubmed/22842346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2376
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