LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

BACKGROUND: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic act...

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Hlavní autoři: Desimmie, Belete Ayele, Schrijvers, Rik, Demeulemeester, Jonas, Borrenberghs, Doortje, Weydert, Caroline, Thys, Wannes, Vets, Sofie, Van Remoortel, Barbara, Hofkens, Johan, De Rijck, Jan, Hendrix, Jelle, Bannert, Norbert, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671127/
https://ncbi.nlm.nih.gov/pubmed/23721378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-57
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