LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

BACKGROUND: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic act...

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Autori principali: Desimmie, Belete Ayele, Schrijvers, Rik, Demeulemeester, Jonas, Borrenberghs, Doortje, Weydert, Caroline, Thys, Wannes, Vets, Sofie, Van Remoortel, Barbara, Hofkens, Johan, De Rijck, Jan, Hendrix, Jelle, Bannert, Norbert, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671127/
https://ncbi.nlm.nih.gov/pubmed/23721378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-57
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