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LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
BACKGROUND: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic act...
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| Autori principali: | , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671127/ https://ncbi.nlm.nih.gov/pubmed/23721378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-57 |
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