LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

BACKGROUND: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic act...

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Bibliographic Details
Main Authors: Desimmie, Belete Ayele, Schrijvers, Rik, Demeulemeester, Jonas, Borrenberghs, Doortje, Weydert, Caroline, Thys, Wannes, Vets, Sofie, Van Remoortel, Barbara, Hofkens, Johan, De Rijck, Jan, Hendrix, Jelle, Bannert, Norbert, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671127/
https://ncbi.nlm.nih.gov/pubmed/23721378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-57
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