LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

BACKGROUND: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic act...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Desimmie, Belete Ayele, Schrijvers, Rik, Demeulemeester, Jonas, Borrenberghs, Doortje, Weydert, Caroline, Thys, Wannes, Vets, Sofie, Van Remoortel, Barbara, Hofkens, Johan, De Rijck, Jan, Hendrix, Jelle, Bannert, Norbert, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2013
विषय:
Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671127/
https://ncbi.nlm.nih.gov/pubmed/23721378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-57
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